Is there a fundamental difference between the male and female brain?

Can we claim that, in general, men are inherently better at math and science, or is the disparity between numbers of men and women in scientific fields due only to cultural bias?
If it's only because of cultural bias, then why did that bias develop in the first place?

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I think this issue is interesting, and I can think of several good arguments for both sides. However, I've noticed that those arguments are based mostly on emotion-- the main premise behind most of the points is that the arguer wants their point of persuasion to be true. For example, I would really like to think that men and women are intellectually equal in all areas. I based my decision on what I wanted to be true, and only found supporting evidence afterwards. When responding, try to see if you're doing the same thing.